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Drosophila Developmental Neuroscience and Gene Regulation

The long-term goal of our lab’s research program has been to understand the molecular basis of Drosophila CNS development. The experimental system we studied were the neurons and glia that reside along the midline of the embryonic CNS. Much of our early work studied the Drosophila single-minded bHLH-PAS transcription factor gene, the master regulator of CNS midline cell development. In recent years, we utilized genetic, molecular, genomic, and cellular approaches, including live imaging, to pioneer understanding of Drosophila CNS midline cell development. Our studies revealed the regulatory circuitry controlling neuronal and glial cell fate and differentiation, the properties of midline transcriptional enhancer elements, the control of neuronal and glial cell migration, and how axons and glia interact.


Summer Abroad in Dublin: Medical Biochemistry and Disease Course

Summer 2022, Dr. Stephen Crews will teach BIOL 490 Medical Biochemistry and Disease as part of UNC Science Dublin Study Abroad. The Study Abroad session in Dublin, Ireland will run from June 1 to July 17, 2022.

Michael Artov Accepted to Medical School

Michael Artov, ex-Crews Lab undergraduate researcher, was accepted to medical school at Tulane University School of Medicine. Congratulations to Mike and best wishes for a terrific medical career.

Review of Drosophila Embryonic CNS Development Published

Steve Crews published a comprehensive review in the journal Genetics “Drosophila Embryonic CNS Development: Neurogenesis, Gliogenesis, Cell Fate, and Differentiation”.

Crews Lab Image as Art

The eclectic rendering of the Drosophila CNS by former postdoc, Joe Pearson, will continue to be displayed at UNC. Previously, it was featured with additional science art by UNC neuroscientists at the Ackland Art Museum’s 2019 spectacular exhibit “The Beautiful … Continued