Publications

Crews, S.T. (2019). Drosophila embryonic CNS development: neurogenesis, gliogenesis, cell fate, and differentiation. Genetics 213, 1111-1144.

Crews, S.T. (2017). Creating cell type-specific mutants by enhancer mutagenesis. Genes Dev. 31, 629-631.

Pearson, J.C., McKay, D.J., Lieb, J.D. and Crews, S.T. (2016). Chromatin profiling of Drosophila CNS subpopulations identifies active transcriptional enhancers. Development 143, 3723-2732.

Heckscher, E.S., Long, F., Layden, M.J., Chuang, C.H., Manning, L., Richart, J., Pearson, J.C., Crews, S.T., Peng, H., Myers, E. and Doe, C.Q. (2014). Atlas-builder software and the eNeuro atlas: resources for developmental biology and neuroscience. Development 141, 2524-2532.

Pearson, J.C. and Crews, S.T. (2014). Enhancer diversity and the control of a simple pattern of Drosophila CNS midline cell expression. Dev Biol. 15, 466-482.

Pearson, J.C. and Crews, S.T. (2013). Twine: display and analysis of cis-regulatory modules. Bioinformatics 29, 1690-1692.

Manning et al. (2012). A resource for manipulating gene expression and analyzing cis-regulatory modules in the Drosophila CNS. Cell Rep. 2, 1002-1013.

Fontana, J.R. and Crews, S.T. (2012). Transcriptome analysis of Drosophila CNS midline cells reveals diverse peptidergic properties and a role for castor in neuronal differentiation. Dev. Biol. 372, 131-142.

Watson, J.D. and Crews, S.T. (2012). Formation and specification of a Drosophila dopaminergic precursor cell. Development 139, 3316-3325.

Pearson, J.C., Watson, J.D. and Crews, S.T. (2012). Drosophila melanogaster Zelda and Single-minded collaborate to regulate an evolutionarily dynamic CNS midline cell enhancer. Dev. Biol. 366, 420-432.

Wheeler, S.R., Pearson, J.C. and Crews, S.T. (2012). Time-lapse imaging reveals stereotypical patterns of Drosophila midline glial migration. Dev. Biol. 361, 232-244.

Freer, S.M., Lau, D.C., Pearson, J.C., Talsky, K.B. and Crews, S.T. (2011). Molecular and functional analysis of Drosophila single-minded larval central brain expression. Gene Expr. Patterns 11, 533-546.

Stagg, S.B., Guardiola, A.R. and Crews, S.T. (2011). Dual role for Drosophila lethal of scute in CNS midline precursor formation and dopaminergic neuron and motoneuron cell fate. Development 138, 2171-2183.

Watson, J.D., Wheeler, S.R., Stagg, S.B and Crews, S.T. (2011). Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fates. Development 138, 1285-1295.

Jiang, L, Pearson, J.C. and Crews, S.T. (2010). Diverse modes of Drosophila tracheal fusion cell transcriptional regulation. Mech. Dev. 127, 265-280.

Crews, S.T. (2010). Axon-glial interactions at the Drosophila CNS midline. Cell Adh. Migr. 4, 66-70.

Wheeler, S.R., Stagg, S.B. and Crews, S.T. (2009). MidExDB: A database of Drosophila CNS midline cell gene expression. BMC Dev. Biol. 9, 56-64.

Crews, S.T. and Pearson, J.C. (2009). Transcriptional autoregulation during development. Curr. Biol. 19, R241-246.

Wheeler, S.R., Banerjee, S., Blauth, K., Rogers, S.L., Bhat, M.A. and Crews, S.T. (2009). Neurexin IV and Wrapper interactions mediate Drosophila midline glial migration and axonal ensheathment. Development 136, 1147-1157.

Wheeler, S.R., Stagg, S.B. and Crews, S.T. (2008). Multiple Notch signaling events control Drosophila CNS midline neurogenesis, gliogenesis and neuronal identity. Development 135, 3071-3079.

Jiang, L., Rogers, S. and Crews, S.T. (2007). The Drosophila Dead end Arf-like3 GTPase controls vesicle trafficking during tracheal fusion cell morphogenesis. Dev. Biol. 311, 487-499.

Jiang, L. and Crews, S.T. (2007). Transcriptional specificity of the Drosophila Dysfusion bHLH-PAS protein and the control of tracheal fusion cell gene regulation. J. Biol. Chem. 282, 28659-28668.

Crews, S.T. and Brenman, J.E. (2006). spineless provides a little backbone for dendritic morphogenesis. Genes & Dev. 20, 2773-2778.

Jiang, L. and Crews, S. T. (2006). dysfusion transcriptional programming of Drosophila tracheal migration, adhesion, and fusion. Mol. Cell. Biol. 26, 6547-6556.

Wheeler, S.R., Kearney, J.B., Guardiola, A.R. and Crews, S.T. (2006). Single-cell mapping of neural and glial gene expression in the developing Drosophila CNS midline cells. Dev. Biol. 294, 509-524.

Kearney, J.B., Wheeler, S.R., Estes, P., Parente, B. and Crews, S.T. (2004). Gene expression profiling of the developing Drosophila CNS midline cells. Dev. Biol. 275, 473-492.

Sugimura, K., Satoh, D., Estes, P., Crews, S. and Uemura, T. (2004).Development of morphological diversity of dendrites in Drosophila by the BTB-zinc finger protein Abrupt. Neuron 43, 809-822.

Crews, S.T. (2003). Drosophila bHLH-PAS developmental regulatory proteins. In: PAS proteins: regulators and sensors of development and physiology. (S. T. Crews, ed.), Kluwer.

Jiang, L. and Crews, S.T. (2003). The Drosophila dysfusion bHLH-PAS gene controls tracheal fusion and levels of the Trachealess bHLH-PAS protein. Mol. Cell. Biol. 23, 5625-5637.

Mitchell, B. and Crews, S.T. (2002). Expression of the Artemia trachealess gene in the salt gland and epipod. Evol. & Dev. 4, 344-353.

Pielage, J., Steffes, G., Lau, D., Parente, B., Crews, S., Strauss, R. and Klambt, C. (2002). Novel behavioral and developmental defects associated with Drosophila single-minded. Dev Biol. 249, 283-299.

Estes, P., Mosher, J. and Crews, S.T. (2001). Drosophila single-minded represses gene transcription by activating the expression of repressive factors. Dev. Biol. 232, 157-175.

Ma, Y., Certel, K., Gao, Y., Niemitz, E., Mosher, J., Mukherjee, A., Mutsuddi, M., Huseinovic, N., Crews, S.T., Johnson, W.A. and Nambu, J.R. (2000). Functional interactions between Drosophila bHLH/PAS, Sox, and POU transcription factors regulate CNS midline expression of the slit gene. J. Neurosci. 20, 4596-4605.

Crews, S.T. and Fan, C.-M. (1999). Remembrance of things PAS: regulation of development by bHLH-PAS proteins. Curr. Opin. Genet. Dev. 9, 580-587.

Emmons, R.B., Duncan, D., Estes, P., Kiefel, P., Mosher, J., Sonnenfeld, M. Ward, Duncan, I. and Crews, S.T. (1999). The Spineless-Aristapedia and Tango bHLH-PAS proteins interact to control antennal and tarsal development in Drosophila. Development 126, 3937-3945.

Lee, C.-M., Yu, D.-S., Crews, S.T. and Kim, S.-H. (1999). The CNS midline cells and spitz class genes are required for proper patterning of Drosophila ventral neuroectoderm affect cell fate determination and formation of Drosophila ventral neuroblasts. Int. J. Dev. Biol. 43, 305-315.

Mosher, J.T. and Crews, S.T. (1999). Effectene reagent yields high transfection efficiencies with Drosophila melanogaster S2 cells. Qiagen News 4, 11-13.

Matthews, B.B. and Crews, S.T. (1999). The Drosophila center divider gene is expressed in the CNS midline cells and encodes a developmentally regulated protein kinase orthologous to human TESK1. DNA and Cell Biology 18, 435-448.

Kasai, Y., Stahl, S. and Crews, S. (1998). Specification of the Drosophila CNS midline cell lineage, direct control of single-minded transcription by dorsal/ventral patterning genes. Gene Expression 7, 171-189.

Ward, M.P., Mosher, J.T. and Crews, S.T. (1998). Regulation of bHLH-PAS protein subcellular localization during Drosophila embryogenesis. Development 125, 1599-1608.

Crews, S.T. (1998). Control of cell lineage specific development and transcription by bHLH-PAS proteins. Genes & Dev. 12, 607-620.

Hu, S., Sonnenfeld, M., Stahl, S. and Crews, S.T. (1998). Midline Fasciclin: a Drosophila Fasciclin-I-related membrane protein localized to the CNS midline cells and trachea. J. Neurobiology 35, 77-93.

Sonnenfeld, M., Ward, M., Nystrom, G., Mosher, J., Stahl, S. and Crews, S. (1997). The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development. Development 124, 4571-4582.

Nambu, J.R., Chen, W., Hu, S. and Crews, S.T. (1996). The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human Hypoxia-inducible factor 1a and Drosophila Single-minded. Gene 172, 249-254.

Fan, C-M., Kuwana, E., Bulfone, A., Fletcher, C.F., Copeland, N.G., Jenkins, N.A., Crews, S., Martinez, S., Puelles, L., Rubenstein, J.L.R. and Tessier-Lavigne, M. (1996). Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down Syndrome. Mol. & Cell. Neuro. 7, 1-16.

Hu, S., Fambrough, D., Atashi, J.R., Goodman, C.S. and Crews, S.T. (1995). The Drosophila abrupt gene encodes a BTB-zinc finger regulatory protein that controls the specificity of neuromuscular connections. Genes & Dev. 9, 2936-2948.

Wharton, Jr., K. A., Franks, R. G., Kasai, Y. and Crews, S. T. (1994) Control of CNS midline transcription by asymmetric E-box-like elements: similarity to xenobiotic responsive regulation. Development 120, 3563-3569.

Lewis, J.O. and Crews, S.T. (1994) Genetic analysis of the Drosophila single-minded gene reveals a CNS influence on muscle patterning. Mech. Dev. 48, 81-91.

Franks, R.G. and Crews, S.T. (1994). Transcriptional activation domains of the Single-minded bHLH protein are required for CNS midline cell development. Mech. Dev. 45, 269-277.

Kim, S.H. and Crews, S.T. (1993). Influence of Drosophila ventral epidermal development by the CNS midline cells and spitz class genes. Development 118, 893-901.

Wharton, K.A. and Crews, S.T. (1993). CNS midline enhancers of the Drosophila slit and Toll genes. Mechanisms of Development 40, 141-154.

Nambu, J.R., Lewis, J.L. and Crews, S.T. (1993). The development and function of the Drosophila CNS midline cells. Comparative Biochemistry and Physiology 104A, 399-409.

Crews, S., Franks, R., Hu, S., Matthews, B. and Nambu, J. (1992). The Drosophila single-minded gene and the molecular genetics of CNS midline development. J. Exp. Zoology 261, 234-244.

Kasai, Y., Nambu, J.R., Lieberman, P.M., and Crews, S.T. (1992). Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene. Proc. Natl. Acad. Sci. USA 89, 3414-3418.

Nambu, J.R., Lewis, J.O., Wharton, Jr., K.A. and Crews, S.T. (1991). The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development. Cell 67, 1157-1167.

Nambu, J.R., Franks, R.G., Hu, S. and Crews, S.T. (1990). The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells. Cell 63, 63-75.

Thomas, J.B. and Crews, S.T. (1990). Molecular genetics of neuronal development in the Drosophila embryo. FASEB Journal 4, 2476-2482.

Crews, S.T., Thomas, J.B. and Goodman, C.S. (1988). The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product. Cell 52, 143-151.

Thomas, J.B., Crews, S.T. and Goodman, C.S. (1988). Molecular genetics of the single-minded locus: a gene involved in the development of the Drosophila nervous system. Cell 52, 133-141.