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The paper by Pearson and Crews “Twine: display and analysis of cis-regulatory modules” was published in the journal Bioinformatics. This paper describes a computer program created by Joe Pearson for displaying and analyzing gene enhancers or cis-regulatory modules. This program called “Twine” is freely available for download. Twine can display multiple views of enhancer alignments that display DNA sequence motifs and transcription factor binding sites in the context of phylogenetic conservation.

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